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The EBMT-ADWP and the CIBMTR.

Raffaella Greco1, Manuela Badoglio2, Myriam Labopin2

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Summary
This summary is machine-generated.

Hematopoietic stem cell transplantation (HSCT) offers a profound immune reset for severe neurologic autoimmune diseases (ADs). Registries like EBMT and CIBMTR track HSCT for conditions such as multiple sclerosis (MS).

Keywords:
Center for International Blood and Marrow Transplant ResearchEuropean Society for Blood and Marrow TransplantationHematopoietic stem cell transplantationNeurologic autoimmune diseases

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Area of Science:

  • Neurology
  • Immunology
  • Transplantation Medicine

Background:

  • Hematopoietic stem cell transplantation (HSCT) has become a key treatment for severe neurologic autoimmune diseases (ADs) by eliminating disease memory and resetting the immune system.
  • The field of HSCT for ADs is currently in a dynamic developmental phase, with significant data collection efforts underway.
  • Major transplant registries, including the European Society of Blood and Marrow Transplantation (EBMT) and the Center for International Blood and Marrow Transplant Research (CIBMTR), are crucial for tracking these advancements.

Purpose of the Study:

  • To provide an overview of the EBMT and CIBMTR registries concerning HSCT for neurologic autoimmune diseases.
  • To present the current status and publication output related to HSCT for neurologic ADs.
  • To highlight the role of HSCT in managing conditions like multiple sclerosis (MS).

Main Methods:

  • Analysis of data from the EBMT registry, the largest global database for HSCT in ADs, reporting over 3700 transplants.
  • Review of data from the CIBMTR, focusing on autologous HSCT for neurologic conditions in the Americas.
  • Examination of transplant trends and publication outputs for neurologic ADs.

Main Results:

  • The EBMT registry includes over 3700 transplants for ADs, with multiple sclerosis (MS) accounting for approximately 50% of these procedures.
  • In the Americas, 1030 autologous HSCTs were performed for neurologic conditions, with MS representing 96% of these diagnoses.
  • While HSCT activity for MS in the US is relatively low, recent years have seen an increase, with Mexico reporting a sharp rise in these transplants.

Conclusions:

  • HSCT is an integral and standard-of-care treatment for multiple sclerosis and other neurologic autoimmune diseases.
  • Registry data from EBMT and CIBMTR are vital for understanding the evolving landscape of HSCT for these conditions.
  • Continued monitoring and research are essential to optimize HSCT protocols and outcomes for patients with neurologic ADs.