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Wells syndrome following vaccination: A pediatric case with positive patch test to gelatin
Bárbara Vieira Granja1,2, Maria João Cruz1,3, Pedro Rolo De Matos1
1Department of Dermatology and Venereology, Centro Hospitalar Universitário de São João, Porto, Portugal.
Insights
A child developed Wells syndrome, a skin condition, after receiving the measles, mumps, rubella (MMR) vaccine. Patch testing revealed a gelatin allergy, a vaccine stabilizer found only in the MMR vaccine.
Area of Science:
- Pediatric dermatology
- Vaccinology
- Allergy and immunology
Background:
- Wells syndrome is an idiopathic, recurrent eosinophilic dermatitis.
- Vaccine administration is a common event in pediatric care.
- Allergic reactions to vaccine components can occur.
Abstract:
We report a 12-month-old boy with a skin eruption that developed 15 days after receiving the measles, mumps, rubella (MMR), pneumococcal, and meningococcal vaccines, consistent with the diagnosis of Wells syndrome. Patch testing showed a positive reaction to gelatin, which is used as a stabilizer for both live and inactivated vaccines. Gelatin was only present in the MMR vaccine.
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