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Functional consequences of zinc deficiency.

C J McClain, E J Kasarskis, J J Allen

    Progress in Food & Nutrition Science
    |January 1, 1985
    PubMed
    Summary

    Zinc is vital for numerous bodily functions and enzymes. This review highlights ten key consequences of zinc deficiency, including impaired immune function and anorexia, with new insights into their mechanisms.

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    Area of Science:

    • Biochemistry
    • Human Nutrition
    • Metabolic Medicine

    Background:

    • Zinc is an essential trace element crucial for over 200 metalloenzymes.
    • It plays a vital role in nucleic acid, protein, and membrane metabolism.
    • Knowledge of zinc metabolism, absorption, excretion, and redistribution has expanded significantly.

    Purpose of the Study:

    • To review ten functional consequences of zinc deficiency.
    • To emphasize new discoveries regarding the mechanisms of anorexia and immune dysfunction in zinc deficiency.

    Main Methods:

    • Literature review of studies on zinc metabolism and deficiency.
    • Analysis of functional consequences and their underlying mechanisms.

    Main Results:

    • Zinc deficiency is linked to various conditions like alcoholic liver disease, sickle cell anemia, and Crohn's disease.
    • Impaired zinc absorption is the cause of Acrodermatitis enteropathica.
    • Anorexia and immune dysfunction are significant clinical consequences of zinc deficiency.

    Conclusions:

    • Zinc's importance in physiology and biochemistry is underscored by the diverse symptoms of its deficiency.
    • Further research into the mechanisms of zinc deficiency consequences is clinically important.

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