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Metabolically healthy obesity and left ventricular geometric remodelling in Chinese children

Lili Yang1, Menglong Li2, Huan Wang3

  • 1Department of Epidemiology, School of Public Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Diabetes, Obesity & Metabolism
|August 8, 2024
PubMed

Insights

Metabolically healthy obesity (MHO) in children is linked to increased odds of left ventricular geometric remodelling. This suggests MHO may pose risks to pediatric cardiac health.

Area of Science:

  • Pediatric Cardiology
  • Metabolic Health
  • Obesity Research

Background:

  • Childhood obesity is a growing concern with potential long-term health implications.
  • Metabolically healthy obesity (MHO) is characterized by obesity in the absence of metabolic syndrome components.
  • The impact of MHO on cardiovascular structure in children requires further investigation.

Purpose of the Study:

  • To examine the association between MHO and left ventricular (LV) geometric remodelling in Chinese children.
  • To compare cardiac remodeling in children with MHO versus metabolically healthy normal weight children.

Main Methods:

  • Cross-sectional study of 2871 Chinese children aged 6-11 years.
  • Weight status defined by BMI; metabolic status by 2018 consensus criteria (blood pressure, lipids, glucose).
  • Left ventricular geometric remodelling assessed, and multinomial logistic regression used to determine associations.

Main Results:

  • Children with MHO showed significantly higher odds of LV geometric remodelling compared to metabolically healthy normal weight children.
  • Odds ratios for concentric remodelling, eccentric hypertrophy, and concentric hypertrophy were elevated in MHO.
  • Metabolically unhealthy obesity also showed increased odds of LV remodelling, while metabolically unhealthy normal weight did not.

Conclusions:

  • MHO in children is associated with an increased likelihood of left ventricular geometric remodelling.
  • These findings indicate that MHO may not be a benign condition and could impact children's cardiac health.
Abstract

Keywords:
childrenleft ventricular geometric remodellingmetabolically healthy obesity

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