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Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

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Relationship Between Posttraumatic Headache and Depression After Mild Traumatic Brain Injury.

Marissa L Beal¹, Kevin J Psoter¹, Kathleen T Bechtold¹

¹Department of Psychiatry and Behavioral Health, Pennsylvania State University College of Medicine, Hershey (Beal); Department of Pediatrics (Psoter), Department of Physical Medicine and Rehabilitation (Bechtold), and Department of Psychiatry and Behavioral Sciences (Peters, Rao, Roy), Johns Hopkins University School of Medicine, Baltimore; Johns Hopkins University Krieger School of Arts and Sciences, Baltimore (Nagpaul); Neurological Diseases, BRAINBox Solutions, Richmond, Virginia (Van Meter); Department of Computational Medicine and Bioinformatics (Falk) and Department of Emergency Medicine (Korley), University of Michigan Medical School, Ann Arbor.

The Journal of Neuropsychiatry and Clinical Neurosciences

|August 8, 2024

Summary

Patients with acute posttraumatic headache (PTH) after mild traumatic brain injury (mTBI) are at higher risk for persistent PTH and depression. Early PTH detection can help identify individuals needing monitoring for these conditions.

Keywords:

Depression Emergency Department Head Injury HeadSMART Study Posttraumatic Headache Traumatic Brain Injury

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Published on: June 20, 2017

Area of Science:

Neuroscience
Psychiatry
Trauma Care

Background:

Mild traumatic brain injury (mTBI) can result in persistent psychiatric and somatic symptoms.
Posttraumatic headache (PTH) and depression are common sequelae of mTBI.
The relationship between acute PTH and later depressive symptoms requires further elucidation.

Purpose of the Study:

To establish the association between PTH and depression following mTBI.
To determine if immediate PTH presence post-injury predicts future depressive symptoms up to 6 months.

Main Methods:

Secondary analysis of the prospective HeadSMART study data.
Included 265 adult mTBI patients assessed in the emergency department.
Utilized Rivermead Post-Concussion Symptoms Questionnaire for acute PTH (aPTH) and Patient Health Questionnaire-9 for depression at baseline and 1, 3, 6 months.

Main Results:

Patients with aPTH within 24 hours were more likely to experience PTH at 1, 3, and 6 months.
Acute PTH was associated with more severe depressive symptoms and higher likelihood of clinical depression at all follow-up points.
Persistent PTH and depression were significantly correlated with initial PTH presence.

Conclusions:

Acute PTH within 24 hours of mTBI is a predictor of persistent PTH and depressive symptoms.
Emergency department assessment of aPTH can identify patients at risk for prolonged recovery.
Monitoring for PTH and depression is recommended for patients with acute PTH post-mTBI.