Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 17, 2025

Porcine As a Training Module for Head and Neck Microvascular Reconstruction
07:43

Porcine As a Training Module for Head and Neck Microvascular Reconstruction

Published on: September 29, 2018

7.7K

Chimeric Versus Multiple Simultaneous Free Flaps for Head and Neck Reconstruction.

Johnny Wang1, Theresa Tharakan1, Ryan S Jackson1

  • 1Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|August 8, 2024
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Development of Novel mRNA Classifiers to Stratify Preoperative Thyroid Tumor Risk.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same author

The Impact of Patient-Provider Relationships on Prostate Cancer Screening: A Cross-Sectional Analysis of the All of Us Research Program.

Urology practice·2026
Same author

High-avidity TCR signaling induces a distinct KLR-positive exhaustion state in human tumor-infiltrating CD8 T cells associated with immunotherapy response.

bioRxiv : the preprint server for biology·2026
Same author

Clinical behavior and predictors of survival in major salivary gland secretory carcinoma.

Oral oncology·2026
Same author

Isoform-specific cofactor recruitment through the intrinsically disordered N-terminus of p63 underlies differential transcriptional activities.

bioRxiv : the preprint server for biology·2026
Same author

Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate.

Cancer discovery·2026

Chimeric flaps offer shorter hospital stays but have a higher major complication rate compared to multiple flaps in head and neck reconstruction. Both techniques are viable, with careful patient selection optimizing outcomes.

Area of Science:

  • Microsurgery
  • Head and Neck Reconstruction
  • Plastic Surgery

Background:

  • Large head and neck defects present significant reconstructive challenges for microvascular surgeons.
  • Chimeric and multiple free flaps are surgical techniques used for complex tissue reconstruction.

Purpose of the Study:

  • To compare surgical outcomes and postoperative complications between chimeric flaps and multiple flaps.
  • To assess the effectiveness of chimeric flaps versus multiple flaps in head and neck reconstruction.

Main Methods:

  • Retrospective review of 113 patients undergoing chimeric or multiple simultaneous free tissue transfer (June 2016 - October 2023).
  • Primary outcome: complication rate (major vs. minor). Secondary outcomes: operative time, length of hospitalization, flap survival.
Keywords:
free flapshead and neck neoplasmspostoperative complications

More Related Videos

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible
10:42

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible

Published on: January 28, 2020

6.5K
Creating Avian Forebrain Chimeras to Assess Facial Development
04:10

Creating Avian Forebrain Chimeras to Assess Facial Development

Published on: February 18, 2021

1.1K

Related Experiment Videos

Last Updated: Jun 17, 2025

Porcine As a Training Module for Head and Neck Microvascular Reconstruction
07:43

Porcine As a Training Module for Head and Neck Microvascular Reconstruction

Published on: September 29, 2018

7.7K
A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible
10:42

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible

Published on: January 28, 2020

6.5K
Creating Avian Forebrain Chimeras to Assess Facial Development
04:10

Creating Avian Forebrain Chimeras to Assess Facial Development

Published on: February 18, 2021

1.1K

Main Results:

  • No significant difference in operative times or minor complications between chimeric and multiple flaps.
  • Chimeric flaps were associated with a shorter length of hospitalization.
  • Major complication rate was higher for chimeric flaps (42.1%) compared to multiple flaps (22.7%), P=.03.

Conclusions:

  • Both chimeric and multiple flaps yield acceptable complication rates when used appropriately for head and neck defects.
  • Chimeric flaps are a valuable option for patients with prior radiation or radical resection.
  • Individual patient profiles and institutional capabilities should guide the choice between chimeric and multiple flaps for optimal outcomes.