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Updated: Jun 17, 2025

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Published on: January 22, 2020
Anti-TNFα in inflammatory bowel disease: from originators to biosimilars
Zhen Zeng1,2,3, Hao Lin1,2,3, Mingshan Jiang1,2,3
1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
Abstract:
The introduction of anti-tumor necrosis factor α (TNFα) biologics significantly innovated inflammatory bowel disease (IBD) treatment and increased medical costs. The recent expiration of patents of some anti-TNFα biologics (such as infliximab and adalimumab) facilitated the development of biosimilars. Comparable pharmacokinetic, efficacy, safety, and immunogenicity profiles between anti-TNFα originators and biosimilars were demonstrated in different studies. Anti-TNFα biosimilars hold promise for reducing the high cost of biologics and increasing patient access to biologics. In this review, we outline the current data on the use of anti-TNFα originators and biosimilars in patients with IBD, with a focus on the efficacy, safety, and immunogenicity profiles of infliximab and adalimumab biosimilars. The potential benefits, challenges, and future directions of anti-TNFα biosimilars are also discussed in the review.
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