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Updated: May 5, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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Genome-Wide Mendelian Randomization Study Reveals Druggable Genes for Cerebral Small Vessel Disease

Xin-Zhuang Yang1,2, Mei-Ying Huang1, Fei Han1

  • 1Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China (X.-Z.Y., M.-Y.H., F.H., J.-N., L.-X.Z., M.Y., D.-D.Z., Y.-C.Z.).

Stroke
|August 8, 2024
PubMed
Summary

This study used Mendelian randomization to find potential drug targets for cerebral small vessel disease (CSVD). Five druggable genes, including ALDH2 and KLHL24, show promise for CSVD treatment.

Keywords:
Mendelian randomization analysisbraincerebral small vessel diseasesgene expressiongenome-wide association study

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