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Comparison of the Effect of Different Treatment Doses of Intrastromal Vancomycin in a Rabbit Model of
Abdullah Bayrak1,2, Serdal Çelebi2, Fatma Avcıoğlu3
1Department of Ophthalmology, Macuria- Die Makulaexperten Augenpraxis, Meckenbeuren, Germany.
Purpose:
To compare the effect of different doses of vancomycin on a rabbit model of MRSA keratitis.
Methods:
Twenty-four eyes of 24 New-Zealand White rabbits were included in the study. MRSA keratitis was applied to 24 left eyes of 24 New Zealand rabbits. Twenty-four hours after MRSA inoculation; 0.5 mg/0.1 mL, 1 mg/0.1 mL, and 2 mg/0.1 mL and balanced salt solution were administered to 6 rabbits in 4 groups, respectively.
Results:
The effect of different doses of vancomycin on reducing bacterial load was found to be statistically significant when each was compared to the control group (p = 0.006). When comparing the dosages with each other, no superiority was shown (p = 0.297, p = 0.749, p = 0.262 respectively). There was a significant increase in the posttreatment total clinical score in the control and 2 mg/0.1 mL groups compared to the pretreatment score (p = 0.001, p = 0.001 respectively).
Conclusion:
It is emphasized that necessary treatment can be achieved by administering less antibiotic (0.5 mg/0.1 mL) to the corneal intrastromal area.
