Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Menstrual dysfunction in pathophysiologic states.

L S Neinstein

    The Western Journal of Medicine
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    The menstrual cycle relies on complex hormonal signals from the brain and ovaries. Factors like stress, illness, and weight loss can disrupt these signals, affecting reproductive function.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The treatment of adolescents with a chronic illness: physicians must go beyond the medical model.

    The Western journal of medicine·2001
    Same author

    Breast disease in adolescents and young women.

    Pediatric clinics of North America·1999
    Same author

    Uterine myomas in adolescents: case reports and a review of the literature.

    Journal of pediatric and adolescent gynecology·1996
    Same author

    Comparison between vaginal swab and endocervical swab during pelvic examination.

    The Journal of adolescent health : official publication of the Society for Adolescent Medicine·1994
    Same author

    Prevalence and longitudinal study of breast masses in adolescents.

    The Journal of adolescent health : official publication of the Society for Adolescent Medicine·1993
    Same author

    Comparison of cytobrush with Cervex-Brush for endocervical cytologic sampling.

    The Journal of adolescent health : official publication of the Society for Adolescent Medicine·1992

    Area of Science:

    • Reproductive endocrinology
    • Neuroendocrinology
    • Human physiology

    Background:

    • The menstrual cycle is regulated by intricate interactions between the central nervous system, hypothalamus, pituitary gland, and ovaries.
    • Normal function requires pulsatile secretion of gonadotropin-releasing hormone (GnRH), leading to pulsatile luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release.
    • A surge in LH is critical for ovulation.

    Purpose of the Study:

    • To elucidate the complex regulatory mechanisms of the menstrual cycle.
    • To identify potential disruptions to normal menstrual function caused by various pathophysiologic states.
    • To explore the impact of chronic illness and weight loss on hormonal regulation.

    Main Methods:

    • Review of existing literature on neuroendocrine control of the menstrual cycle.

    Related Experiment Videos

  • Analysis of hormonal feedback loops involving the hypothalamus, pituitary, and ovaries.
  • Examination of the effects of external factors on reproductive hormones.

    • Main Results:

    • Pathophysiologic states such as stress, exercise, and drug use can interfere with menstrual cycle regulation at multiple levels.
    • Chronic illness may impact beta-endorphin levels and hypothalamic function.
    • Significant weight loss, including in conditions like anorexia nervosa, can alter estrogen metabolism, affecting hypothalamic or pituitary function.

    Conclusions:

    • The menstrual cycle is highly sensitive to disruptions in neuroendocrine signaling.
    • Chronic illness and weight loss represent significant factors that can impair normal reproductive hormonal balance.
    • Understanding these disruptions is crucial for managing reproductive health in affected individuals.