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Characterization of the ciliary beating efficiency in primary diffuse chronic rhinosinusitis
M Renaud1, A Venkatasamy2, E Escudier3
1INSERM, U955, Creteil, France; CNRS, EMR 7000, Creteil, France; Universitat Paris-Est Creteil, Faculty de Santa, Creteil, France; AP-HP, Hospital Henri Mondor, Service de Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale, Creteil, France.
Abstract:
Ciliary dysfunction may result in chronic airway inflammation and infection causing injury and structural changes to the airway epithelium, leading to a variety of diseases, like bronchiectasis and primary diffuse chronic rhinosinusitis (CRS). Currently, ciliary beating analysis has mainly been studied through the measure of the ciliary beating frequency (CBF) by high-speed digital video microscopy (HSDV). However, a normal CBF has been described in different forms of primary and acquired ciliary dyskinesia.
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It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...