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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Gut mycobiome alterations and implications for liver diseases
Suling Zeng1, Bernd Schnabl2,3
1Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Plos Pathogens
|August 8, 2024
Summary
Changes in gut fungi (mycobiome) are linked to chronic liver disease progression. Fungal translocation and metabolites contribute to liver damage, highlighting the mycobiome's role in disease development.
Area of Science:
- Gastroenterology and Hepatology
- Microbiology
- Immunology
Background:
- Chronic liver disease poses a substantial global health challenge.
- The gut mycobiome, or fungal community, is increasingly recognized for its role in liver disease pathogenesis.
- Fungal dysbiosis can compromise intestinal barrier integrity, facilitating fungal translocation.
Purpose of the Study:
- To review recent advancements in understanding gut mycobiome diversity in liver diseases.
- To explore the causative links between gut fungi and liver disease development.
- To highlight the impact of fungal translocation and the intrahepatic mycobiome on disease progression.
Main Methods:
- Literature review of current research on gut mycobiome and liver disease.
- Analysis of studies investigating fungal dysbiosis and its consequences.
- Examination of research on fungal metabolites and immune responses in liver pathology.
Main Results:
- Gut mycobiome alterations are associated with various chronic liver diseases.
- Fungal translocation, fungal metabolites, and fungus-induced immune cells are key drivers of liver disease.
- The intrahepatic mycobiome may also influence disease progression.
Conclusions:
- The gut mycobiome is a critical factor in the development and progression of chronic liver disease.
- Targeting fungal dysbiosis and translocation presents potential therapeutic strategies for liver diseases.
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