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[Insulin--a regulator of exocrine pancreas function?]
Zeitschrift Fur Gastroenterologie
|December 1, 1985
Summary
Insulin significantly impacts exocrine pancreas function, influencing nutrient uptake, protein synthesis, and enzyme release. This review explores insulin
Area of Science:
- Endocrinology
- Gastroenterology
- Cell Biology
Context:
- The exocrine pancreas plays a crucial role in digestion.
- Insulin, primarily known for its metabolic functions, may also regulate exocrine pancreatic activity.
- Understanding this relationship is vital for metabolic and digestive disease research.
Purpose:
- To review existing experimental data on insulin's effects on the exocrine pancreas.
- To evaluate the evidence supporting a significant role for insulin in exocrine pancreatic regulation.
- To discuss both short-term and long-term effects of insulin in vitro and in vivo.
Summary:
- Morphological links between endocrine and exocrine pancreas are described.
- Insulin receptors on exocrine acini and their regulation are discussed.
- Exocrine function in diabetes and insulin's effects on glucose/amino acid uptake, protein synthesis, and enzyme release are detailed.
- Long-term effects and the role of insulin-like growth factors are also considered.
Impact:
- Highlights the multifaceted role of insulin beyond glucose metabolism.
- Provides a comprehensive overview for researchers investigating pancreatic physiology and disease.
- Suggests potential therapeutic targets for exocrine pancreatic dysfunction.