If CE affects infertile women's outcomes after surgery?

Area of Science:

• Reproductive Medicine
• Gynecology
• Pathology

Background:

• Chronic endometritis (CE) is a condition affecting the uterine lining.
• Its prevalence and impact on fertility outcomes, particularly after reproductive surgery, require further investigation.

Purpose of the Study:

• To determine the prevalence of chronic endometritis in infertile patients undergoing reproductive surgery.
• To assess the effect of chronic endometritis on spontaneous pregnancy rates post-surgery.

Main Methods:

• Retrospective collection of clinical data from 81 infertile patients who underwent laparoscopic and hysteroscopic surgery.
• Endometrial samples were pathologically examined using immunohistochemical staining for CD38 and CD138 to diagnose CE.
• Patients were followed up to ascertain pregnancy outcomes after surgery.

Main Results:

• Chronic endometritis was diagnosed in 31.82% of the study cohort (25/81 patients).
• No significant differences were observed in demographic or intraoperative conditions between CE and non-CE groups.
• Patients with CE showed a trend towards a longer time to conception and a lower spontaneous pregnancy rate, though not statistically significant (p=0.467 and p=0.132, respectively).
• Live birth rates did not differ significantly between groups among those who achieved pregnancy.

Conclusions:

• Chronic endometritis is prevalent in infertile patients undergoing reproductive surgery.
• The presence of chronic endometritis did not demonstrate a statistically significant impact on spontaneous pregnancy rates or live birth rates following reproductive surgery.