Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Outcomes of Contemporary Bariatric Surgical Procedures: A Nationwide Cohort Study.

Journal of obesity & metabolic syndrome·2026
Same author

SMaRT-Net: A novel framework of 7T brain MRI superresolution for Alzheimer's disease diagnosis and mild cognitive impairment prognostication.

NeuroImage·2026
Same author

Proteomic Profiling of Human Extracellular Vesicles Reveals Diagnostic Biomarkers for Colon Adenocarcinoma.

Journal of extracellular vesicles·2026
Same author

Vertical numbering-up microfluidic architecture for scalable and homogeneous lipid nanoparticle production.

Lab on a chip·2026
Same author

Development of a customizable vascularization strategy using a modular microfluidic platform for fibroblast-free vascularized tissue.

Materials today. Bio·2026
Same author

In Vitro Antioxidant and Cellular Activities of Functionalized Spermidine by Conjugating with Ascorbic Acid in Human Skin Cells.

Molecules (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jun 16, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

42.1K

Bone-on-a-chip simulating bone metastasis in osteoporosis.

Sunghan Lee1,2, Young Gyun Kim1,2, Hyo-Il Jung1,3

  • 1School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seadaemun-gu, Seoul 03722, Republic of Korea.

Biofabrication
|August 8, 2024
PubMed
Summary

A novel bone-on-a-chip model effectively simulates osteoporosis and bone metastasis, revealing increased cancer cell activity in osteoporotic conditions due to vascular permeability. This technology aids drug development for bone disorders.

Keywords:
bone metastasisbone-on-a-chipmineralization levelosteoporotic conditionvascular permeability

More Related Videos

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
06:00

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines

Published on: September 13, 2017

7.1K
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

6.7K

Related Experiment Videos

Last Updated: Jun 16, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

42.1K
Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
06:00

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines

Published on: September 13, 2017

7.1K
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

6.7K

Area of Science:

  • Biomedical Engineering
  • Oncology
  • Bone Biology

Background:

  • Osteoporosis is a prevalent bone disorder that increases the risk of bone metastases.
  • Current osteoporosis treatments are long-term, and bone metastasis lacks a cure, necessitating new drug development.
  • Traditional animal models for drug development are ethically problematic, costly, and time-consuming.

Purpose of the Study:

  • To develop a "bone-on-a-chip" model for studying osteoporosis and bone metastasis.
  • To investigate the behavior of breast cancer cells in simulated normal, osteopenic, and osteoporotic bone conditions.
  • To identify mechanisms underlying enhanced bone metastasis in osteoporosis.

Main Methods:

  • Co-culturing osteoblasts, osteocytes, and osteoclasts within an extracellular matrix to mimic different bone densities.
  • Integrating breast cancer cells into the "bone-on-a-chip" to simulate bone metastasis.
  • Analyzing cancer cell activity and vascular permeability across varied bone conditions.

Main Results:

  • Bone metastasis was significantly more active in the simulated osteoporotic bone conditions.
  • Increased vascular permeability was identified as a key factor promoting bone metastasis in osteoporosis.
  • The "bone-on-a-chip" model successfully differentiated metastatic activity based on bone health.

Conclusions:

  • The developed "bone-on-a-chip" serves as a viable platform for osteoporosis and bone metastasis research.
  • This model can supplement animal testing, offering a more ethical and efficient alternative for drug development.
  • Understanding the role of vascular permeability in osteoporotic bone metastasis opens new avenues for therapeutic strategies.