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The effect of cholecystokinin on postoperative bowel function.
Acta Chirurgica Scandinavica
|January 1, 1985
Summary
Cholecystokinin (CCK) did not improve post-operative intestinal motility in a randomized trial. This study found no significant difference between CCK and placebo for treating paralytic ileus.
Area of Science:
- Gastroenterology
- Surgical Research
- Pharmacology
Background:
- Post-operative paralytic ileus is a common complication after abdominal surgery.
- Cholecystokinin (CCK) is a hormone that stimulates gastrointestinal motility.
- Previous research has explored CCK's potential to accelerate the return of bowel function.
Purpose of the Study:
- To evaluate the efficacy of Cholecystokinin (CCK) in accelerating the return of intestinal motility after surgery.
- To compare the effects of CCK versus placebo on post-operative paralytic ileus.
Main Methods:
- A randomized, double-blind trial was conducted.
- Sixty patients were enrolled in the study.
- Intestinal motility was assessed using both subjective and objective measures.
Main Results:
- No statistically significant difference in the return of post-operative intestinal motility was observed between the group receiving Cholecystokinin (CCK) and the placebo group.
- Both subjective and objective assessments showed similar outcomes for CCK and placebo.
Conclusions:
- Cholecystokinin (CCK) administration does not appear to be effective in preventing or treating post-operative paralytic ileus.
- Further research may be needed to explore other therapeutic strategies for managing post-operative ileus.