Evidence-Based Review on Symptomatic Management of Huntington's Disease

Area of Science:

• Neuroscience and Neurology
• Clinical Medicine

Background:

• Huntington's disease (HD) is a progressive neurodegenerative disorder impacting motor, cognitive, and behavioral functions.
• HD significantly diminishes patient quality of life, necessitating effective symptomatic management strategies.

Purpose of the Study:

• To systematically review current pharmacological and nonpharmacological interventions for managing 23 symptoms of Huntington's disease.
• To provide an evidence-based summary for the symptomatic treatment of HD.

Main Methods:

• Systematic literature search adhering to PRISMA guidelines, covering studies up to August 2022.
• Analysis focused on interventions targeting motor, neuropsychological, cognitive, and other symptom domains of HD.

Main Results:

• Identified and reviewed existing interventions for a wide spectrum of Huntington's disease symptoms.
• Highlighted the current state of evidence for various management approaches.

Conclusions:

• A comprehensive overview of symptomatic management for Huntington's disease is presented.
• Emphasizes the critical need for more high-quality clinical trials to establish robust, evidence-based guidelines for HD care.