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Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Cancer-Critical Genes I: Proto-oncogenes01:33

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Related Experiment Video

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Cervical cancer: a new era.

Giuseppe Caruso1,2,3, Matthew K Wagar4, Heng-Cheng Hsu5,6,7

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International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
|August 8, 2024
PubMed
Summary

Cervical cancer, a leading global health concern, is managed through surgery, chemotherapy, and novel therapies like immune checkpoint inhibitors. This review details current cervical cancer treatments and recent advancements.

Keywords:
Cervical CancerImmunotherapyRadiotherapySLN and LympadenectomySurgery

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Area of Science:

  • Oncology
  • Gynecologic Oncology

Background:

  • Cervical cancer is the fourth most common cancer globally in women.
  • Current management involves surgery, radiotherapy, chemotherapy, and newer systemic therapies.

Purpose of the Study:

  • To provide a comprehensive overview of current cervical cancer management.
  • To discuss recent practice-changing updates in cervical cancer treatment.

Main Methods:

  • Review of current literature on cervical cancer treatment modalities.
  • Analysis of recent advancements in surgical, radiological, and systemic therapies.

Main Results:

  • Standard treatments include surgery, radiotherapy, and platinum-based chemotherapy.
  • Novel therapies, particularly immune checkpoint inhibitors, show significant survival benefits.

Conclusions:

  • Cervical cancer management is evolving with advances in personalized therapies.
  • Immune checkpoint inhibitors have significantly improved outcomes for advanced/recurrent cervical cancer.