Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Favipiravir tissue distribution and inhibitory quotients in preclinical models: towards a pipeline for evidence-based antiviral repurposing.

The Journal of antimicrobial chemotherapy·2026

Same author

Multimodal data integration to determine viral and innate immune kinetics in human airway epithelium.

PLoS computational biology·2026

Same author

Exposure history shapes SARS-CoV-2 viral dynamics in non-human primates and provides insights into correlates of protection against infection and transmission.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026

Same author

High Nasopharyngeal SARS-CoV-2 Load and Delayed Clearance in Hospitalized Patients With Blood Autoantibodies Neutralizing Type I Interferons.

The Journal of infectious diseases·2026

Same author

Viral dynamics of the Respiratory Syncytial Virus during experimental human challenge: insights for transmission and protection.

The Journal of infectious diseases·2026

Same author

Preclinical efficacy of a favipiravir and nitazoxanide combination against Rift Valley Fever Virus.

Antiviral research·2026

Search research articles

Related Experiment Video

Updated: Jun 17, 2025

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Humanized NOD/SCID/IL2rγ^null (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

Modelling HIV-1 control and remission.

Bharadwaj Vemparala¹, Shreya Chowdhury¹, Jérémie Guedj²

¹Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India.

NPJ Systems Biology and Applications

|August 8, 2024

Summary

This summary is machine-generated.

Mathematical modeling advances HIV-1 remission research, aiding the development of interventions to end lifelong antiretroviral therapy for millions. Future work will address remaining challenges for successful translation.

More Related Videos

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

Related Experiment Videos

Last Updated: Jun 17, 2025

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Humanized NOD/SCID/IL2rγ^null (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

Area of Science:

Virology
Mathematical Biology
Immunology

Background:

Current standard-of-care for HIV-1 infection is lifelong antiretroviral therapy.
Significant progress is being made in developing interventions for long-term HIV-1 remission.
Mathematical modeling plays a crucial role in understanding and optimizing these interventions.

Purpose of the Study:

To survey recent advances in mathematical modeling for HIV-1 control and remission.
To highlight the contributions of mathematical modeling to HIV-1 remission research.
To discuss future directions and challenges in translating these interventions.

Main Methods:

Review of recent literature on mathematical modeling of HIV-1 control.
Analysis of modeling approaches for understanding natural and post-treatment control.
Examination of modeling frameworks for intervention optimization.

Main Results:

Mathematical modeling has elucidated mechanisms of HIV-1 control and loss of control.
Modeling has quantified intervention effects and informed rational optimization strategies.
Despite advances, several key questions remain, posing challenges for clinical translation.

Conclusions:

Mathematical modeling is indispensable for advancing HIV-1 remission strategies.
Continued development of modeling approaches is needed to overcome translation challenges.
Interdisciplinary collaboration is essential for achieving long-term HIV-1 remission.