Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ethics in Research

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Kappa opioid receptors mediate aversion-and it matters.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026

Same author

Epigenome-wide association study of psilocybin-induced methylome changes in alcohol use disorder.

Translational psychiatry·2026

Same author

Investigating Factors Associated With Spontaneous Remission in Individuals With Alcohol Use Disorder-Results From a Multi-Site Longitudinal Cohort Study.

Addiction biology·2026

Same author

Oxa-noribogaine reduces alcohol drinking through aversion learning and by altering glutamatergic activity in the mPFC.

Research square·2026

Same author

Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons.

eLife·2026

Same author

Engaging Gut-to-Brain Signalling to Treat Alcohol Use Disorder.

Addiction biology·2026

Search research articles

Related Experiment Video

Updated: Jun 17, 2025

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Good Practice Guideline for Preclinical Alcohol Research: The STRINGENCY Framework.

Marcus W Meinhardt^1,2, Björn Gerlach^3,4,5, Rainer Spanagel^6,7

¹Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. marcus.meinhardt@zi-mannheim.de.

Current Topics in Behavioral Neurosciences

|August 8, 2024

Summary

This summary is machine-generated.

The preclinical research reproducibility crisis is addressed by STRINGENCY, a new framework integrating guidelines to enhance the reliability of scientific findings and improve human translation. This approach aims to minimize research waste and increase the impact of preclinical alcohol and behavioral studies.

Keywords:

Guideline Methodology Preclinical research Replication crisis Reproducibility

More Related Videos

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

Related Experiment Videos

Last Updated: Jun 17, 2025

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

Area of Science:

Preclinical alcohol research
Behavioral science
Biomedical research

Background:

The replication crisis, a significant issue in biomedical research, stems from poor methodology and hinders the translation of preclinical findings to human applications.
Existing guidelines for research reproducibility are fragmented, lacking a unified framework for implementation.

Purpose of the Study:

To introduce STRINGENCY, an integrative framework designed to enhance the rigor and reproducibility of preclinical alcohol research.
To provide a unified approach to existing guidelines, improving the reliability and translational potential of research.

Main Methods:

STRINGENCY integrates systematic reviews, meta-analysis, preregistration, and multisite experiments.
It emphasizes robust scientific data management (FAIR principles), standardized reporting (ARRIVE guidelines), and transparent publication of all results, including null findings.

Main Results:

The proposed STRINGENCY framework offers a comprehensive solution to the replication crisis in preclinical research.
Implementation of STRINGENCY is expected to improve the quality, reliability, and translational success of scientific research.

Conclusions:

Adoption of the STRINGENCY framework by the scientific community is crucial for improving the reliability and impact of preclinical alcohol and behavioral research.
STRINGENCY aims to minimize the "valley of death" in translational research by enhancing the quality of preclinical studies.