Related Experiment Video

Updated: Jun 17, 2025

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats
05:09

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats

Published on: February 8, 2022

2.6K

The effect of 30 min of supine rest on plasma renin concentrations in paediatric patients

D F Al-Zoubaidi1,2, T H Johannsen1,2, N R Jørgensen3,4,5

  • 1Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Acta Paediatrica (Oslo, Norway : 1992)
|August 9, 2024
PubMed

Insights

Plasma renin concentrations (PRCs) decrease in children after 30 minutes of rest. This finding is crucial for accurate PRC interpretation in pediatric patients, considering postural influences.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Biochemistry

Background:

  • Accurate interpretation of plasma renin concentrations (PRCs) is vital in clinical settings.
  • Understanding the influence of physical activity and posture on PRCs is essential for correct diagnosis.
  • Reference values for adults exist, but data on postural effects in children are limited.

Purpose of the Study:

  • To investigate the effect of 30 minutes of rest on plasma renin concentrations in pediatric patients.
  • To provide data on PRC changes related to posture in children.

Main Methods:

  • Included 41 pediatric patients undergoing arginine or clonidine provocation tests.
  • Collected two blood samples for renin concentration determination: one at baseline (0 min) and one after 30 minutes of rest.
  • Analyzed 86 serum samples in total.

Main Results:

  • A median decrease of 20.5% in renin concentrations was observed after 30 minutes of rest.
  • The observed decrease was consistent across different sexes, ages, medications, and comorbidities.
  • No significant difference in the variance of renin levels was found between the 0 and 30-minute time points.

Conclusions:

  • Pediatric renin concentrations are influenced by postural changes, similar to adults.
  • Clinical interpretation of renin results in children must account for preanalytical conditions, specifically postural positioning.
  • Standardized preanalytical conditions are recommended for consistent PRC measurement in pediatric populations.
Abstract

Keywords:
childprovocation testreninsupine rest

More Related Videos

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.4K
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.1K

Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
52
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
517
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
68
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
77
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
406
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
569