Assessment of Serum Cortisol Levels in Patients with Oral Squamous Cell Carcinoma and Its Correlation with Clinical Staging, Histopathological Grading and Nodal Metastasis: A Prospective Study
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View abstract on PubMed
Summary
This summary is machine-generated.Serum cortisol levels are higher in oral squamous cell carcinoma patients. Elevated cortisol correlates with advanced tumor stage, suggesting its potential as a biomarker for oral cancer progression.
Area Of Science
- Biochemistry
- Oncology
- Endocrinology
Background
- Oral squamous cell carcinoma (OSCC) is a prevalent malignancy.
- Understanding the relationship between physiological markers and cancer progression is crucial for diagnosis and treatment.
Purpose Of The Study
- To evaluate serum cortisol levels in OSCC patients.
- To correlate these levels with tumor staging (TNM), histopathological grading (Bryne's system), and nodal metastasis.
Main Methods
- Prospective study of 25 OSCC patients.
- Serum cortisol levels measured in the morning.
- Correlation analysis with TNM staging, Bryne's grading, and histopathological nodal status.
Main Results
- Patients with OSCC exhibited higher morning serum cortisol levels.
- A statistically significant increase in cortisol was observed with advanced TNM staging (p=0.0001).
- No significant correlation found between cortisol levels and histopathological grading or nodal metastasis.
Conclusions
- Advanced stage OSCC is associated with significantly elevated serum cortisol.
- Cortisol may serve as a potential biomarker reflecting the clinical status of oral cancer.
- Neurohormonal mediators likely influence OSCC cells.
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