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Updated: Jun 17, 2025

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
Familial Spontaneous Keloids: Examining Thoracic Manifestations in Two Brothers
Ioannis Kyriazidis1, Efterpi Demiri2,1, Pericles Foroglou2,1
1Department of Plastic and Reconstructive Surgery, General Hospital Papageorgiou, Thessaloniki, GRC.
Abstract:
Keloids are complex fibroproliferative disorders with diverse clinical presentations. Spontaneous keloids (SKs) represent a rare subtype that emerges without any known preceding traumatic event. This report presents a case of familial spontaneous keloids appearing on the thoracic region in two brothers with no prior history of trauma or keloid occurrence in other family members. The lesions exhibited progressive growth over several years but responded to cycles of triamcinolone treatment. This case underscores an unusual spontaneous occurrence of keloids in the thoracic region of two siblings, highlighting the potential genetic predisposition in the aetiology of these lesions. Additionally, this instance reinforces the concept that keloids can develop spontaneously without any apparent trauma in the affected area.
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