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Updated: Jul 6, 2026

Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase
Published on: July 23, 2009
Open treatment of infected abdominal aortic aneurysm stemming from perineal infection
Andrew Hendrix1, Ankur Makani2, Thomas Crafton2
1University of South Carolina School of Medicine, 6311 Garners Ferry Rd, Columbia, SC 29209, United States.
Abstract:
Infected abdominal aortic aneurysms (AAAs) make up a small minority of AAAs yet are characterized by a high fatality rate, largely attributed to their increased risk of aneurysm rupture. This case details a rare presentation of a 56-year-old man that developed Proteus mirabilis bacteremia secondary to a perineal abscess and subsequently experienced a 3 cm growth of his previously stable AAA over an 8 day period. This case underscores the importance of maintaining a heightened suspicion for infected aortic aneurysms in sick patients and highlights the critical role of surgical management in achieving source control.
Insights
Infected abdominal aortic aneurysms (AAAs) are rare but deadly. A case shows Proteus mirabilis bacteremia rapidly growing a stable AAA, emphasizing prompt diagnosis and surgical intervention for infected aortic aneurysms.
Area of Science:
- Vascular Surgery
- Infectious Diseases
- Aortic Aneurysm Management
Background:
- Infected abdominal aortic aneurysms (IAAs) represent a small fraction of abdominal aortic aneurysms (AAAs) but carry a significantly higher mortality rate due to increased rupture risk.
- Prompt diagnosis and effective management are crucial for improving outcomes in patients with IAAs.
Observation:
- A 56-year-old male presented with Proteus mirabilis bacteremia originating from a perineal abscess.
- This patient had a previously stable 3 cm abdominal aortic aneurysm (AAA).
- The AAA demonstrated rapid growth over an 8-day period following the onset of bacteremia.
Findings:
- The case highlights a rare instance of rapid AAA expansion secondary to bacteremia.
- Proteus mirabilis bacteremia was identified as the likely trigger for the aneurysm's accelerated growth.
- Surgical intervention was critical for achieving source control in this complex case.
Implications:
- Clinicians should maintain a high index of suspicion for infected aortic aneurysms in critically ill patients, especially those with bacteremia.
- Early recognition and aggressive surgical management, including source control, are paramount in managing infected aortic aneurysms.
- This case emphasizes the potential for rapid AAA progression in the setting of systemic infection.
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