Association between genetically plasma proteins and osteonecrosis: a proteome-wide Mendelian randomization analysis
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.This study used Mendelian randomization to investigate causal links between plasma proteins and osteonecrosis. Heme-binding protein 1 (HEBP1) showed a significant positive association, suggesting its potential role in osteonecrosis development.
Area Of Science
- Genetics and Molecular Biology
- Biochemistry
- Medical Research
Background
- Previous research has explored the association between plasma proteins and osteonecrosis.
- The causal relationship between specific plasma proteins and osteonecrosis requires further investigation.
Purpose Of The Study
- To assess the causal relationship between circulating plasma proteins and osteonecrosis risk using Mendelian randomization (MR).
- To identify potential causal circulating proteins and novel drug targets for osteonecrosis.
Main Methods
- Utilized summary-level data from a large protein quantitative trait loci study (35,559 individuals) for 4,907 circulating proteins.
- Employed MR analysis with outcome data from the FinnGen study (1,543 cases, 391,037 controls) for osteonecrosis.
- Conducted phenome-wide MR analysis and candidate drug prediction to identify potential causal proteins and therapeutic targets.
Main Results
- Assessed 1,676 plasma proteins, identifying 71 with suggestive associations with osteonecrosis risk (P < 0.05).
- Heme-binding protein 1 (HEBP1) demonstrated a significant positive association with osteonecrosis risk (OR, 1.40; P = 3.96 × 10⁻⁵).
- The association of HEBP1 was robust across MR methods, with no significant heterogeneity or pleiotropy detected.
Conclusions
- Identified 71 plasma proteins associated with osteonecrosis, highlighting HEBP1, ITIH1, SMOC1, and CREG1 as potential biomarkers.
- Suggests HEBP1 as a potential causal factor and biomarker for osteonecrosis.
- Further research is necessary to validate these identified plasma proteins as reliable biomarkers for osteonecrosis.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
