Related Experiment Video

Updated: Jun 17, 2025

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
12:15

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

8.7K

OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage

Yunxiao Zhong1,2, Xinya Zhang1,2, Ruibing Feng1

  • 1Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.

Medicinal Research Reviews
|August 9, 2024
PubMed

Insights

8-oxoguanine DNA glycosylase 1 (OGG1) is a key target for treating inflammation, cancer, and aging. Inhibiting OGG1 may treat cancer and inflammation, while activating it could combat age-related diseases.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Oxidative DNA damage contributes to diseases like inflammation, cancer, and aging.
  • Current treatments face challenges due to complex mechanisms and limited targets.

Purpose of the Study:

  • To review the multifaceted roles of 8-oxoguanine DNA glycosylase 1 (OGG1).
  • To explore OGG1's potential as a therapeutic target for inflammation, cancer, and aging.
  • To summarize OGG1's regulatory mechanisms in disease.

Main Methods:

  • Systematic review of scientific literature on OGG1.
  • Analysis of OGG1's pro-inflammatory, tumorigenic, and aging regulatory functions.
  • Evaluation of OGG1 inhibitors and activators as therapeutic agents.

Main Results:

  • OGG1 plays a central role in inflammation, tumorigenesis, and aging processes.
  • OGG1 inhibition shows promise for treating inflammation and cancer.
  • OGG1 activation may be beneficial for age-related disorders.

Conclusions:

  • OGG1 is a versatile therapeutic target for multiple life-limiting diseases.
  • Targeting OGG1 offers novel strategies for disease prevention and treatment.
  • Further research into OGG1 modulation is crucial for clinical drug development.
Keywords:
8‐oxoguanine DNA glycosylase 1age‐related disordersinflammationoxidative DNA damage‐related diseasestumors

More Related Videos

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development14:22

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

Published on: April 15, 2013

20.2K
Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

7.4K

Related Concept Videos

Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.5K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
12.5K
DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.1K
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
30.9K
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
35.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K