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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

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Syphilis testing in blood donors, France, 2007 to 2022.

Syria Laperche1, Claire Sauvage2, Sophie Le Cam3

  • 1Direction médicale, EFS Siège, Saint Denis, France.

Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
|August 9, 2024
PubMed
Summary

Syphilis rates in blood donors rose significantly in 2022, primarily affecting males, including men who have sex with men (MSM). Current tests could not reliably distinguish recent from past syphilis infections in these donors.

Keywords:
FranceSyphilisblood donorsdiagnosticepidemiologyscreeningsexually transmitted infections

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Blood Transfusion Safety

Background:

  • Syphilis seropositivity in blood donors (BD) has shown an increasing trend globally.
  • Monitoring syphilis trends in BD is crucial for blood supply safety.

Purpose of the Study:

  • To analyze syphilis seropositivity trends in French blood donors from 2007 to 2022.
  • To identify risk factors associated with syphilis in BD.
  • To evaluate the utility of non-treponemic tests (NTTs) in differentiating recent from past syphilis infections.

Main Methods:

  • Analysis of 45,875,939 blood donations between 2007 and 2022.
  • Investigation of 474 syphilis-positive BD in 2022, including NTT analysis for 429.
  • Collection of syphilis history through post-donation interviews and serological data.

Main Results:

  • Syphilis positivity rates remained stable until 2021, then increased significantly in 2022 (1.74/10,000 donations).
  • Prevalence was higher in males (2.2x overall, 4.1x in 2022), with a notable rise in men who have sex with men (MSM) reporting risk factors (16.7% to 64.9%).
  • NTT data suggested 18% of seropositive donors in 2022 had recent infections, but evaluation was limited due to insufficient historical data.

Conclusions:

  • A considerable increase in syphilis seropositivity among blood donors was observed in 2022, predominantly in males, including MSM.
  • The non-treponemic test (NTT) utility for distinguishing recent from past syphilis infections in blood donors requires further investigation.
  • Enhanced surveillance and risk factor assessment are vital for managing syphilis in blood donation settings.