Functional Movement Disorder as a Prodromal Symptom of Parkinson's Disease-Clinical and Pathophysiological Insights

Area of Science:

• Neurology
• Neuroscience
• Movement Disorders

Background:

• Functional movement disorder (FMD) is a common symptom of functional neurological disorder.
• FMD frequently co-occurs with Parkinson's disease (PD).

Purpose of the Study:

• To review evidence on the temporal relationship between FMD and PD.
• To explore FMD as a potential prodromal symptom of PD.
• To discuss clinical implications and future research directions.

Main Methods:

• Literature review of cohort studies and case series.
• Analysis of the temporal association between FMD onset and PD diagnosis.
• Discussion of potential mechanisms and clinical considerations.

Main Results:

• Emerging evidence suggests FMD can precede a PD diagnosis.
• This temporal relationship indicates FMD may be a prodromal symptom of neurodegeneration.
• Understanding this link is crucial for patient management.

Conclusions:

• FMD may serve as an early indicator of underlying neurodegenerative processes leading to PD.
• Recognizing FMD as a prodromal symptom has significant implications for clinical assessment, investigations, counseling, and follow-up strategies.
• Further research is needed to elucidate the mechanisms and confirm the predictive value of FMD for PD.