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PdMoPtCoNi High Entropy Nanoalloy with d Electron Self-Complementation-Induced Multisite Synergistic Effect for

Xuewei Yang1, Jianxing Feng1, Yuechun Li1

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Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 9, 2024
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High-entropy nanozymes (HEzymes) utilize entropy-driven alloys to boost catalytic efficiency. These novel HEzymes show promise for advanced point-of-care biosensing applications.

Keywords:
DFT calculationsInternet of Thingsheterogeneous catalysishigh‐entropy alloysnanozymes

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Catalysis

Background:

  • Heterogeneous catalysis efficiency is limited by nanozyme activity.
  • High-entropy alloys (HEAs) offer tunable compositions and synergistic effects for enhanced catalysis.
  • Entropy-mediated strategies can reduce reaction activation energy in nanocatalysts.

Purpose of the Study:

  • To develop high-entropy nanozymes (HEzymes) for improved catalytic performance.
  • To investigate the catalytic activity of PdMoPtCoNi HEA nanowires (NWs).
  • To validate the application of HEzymes in portable biosensing devices for point-of-care diagnosis.

Main Methods:

  • Fabrication of PdMoPtCoNi HEA nanowires (NWs).
  • Characterization of HEzymes' structure and electronic properties.
  • Density functional theory (DFT) calculations to understand catalytic mechanisms.
  • Integration of HEzymes with a portable electronic device for biosensing.

Main Results:

  • PdMoPtCoNi HEA NWs exhibited peroxidase-mimicking activity comparable to horseradish peroxidase.
  • DFT calculations revealed enhanced electron abundance and efficient electron transfer in HEA NWs.
  • The HEzymes were successfully integrated into a portable device for digital biosensing.
  • The system demonstrated potential for point-of-care diagnosis of urinary biomarkers.

Conclusions:

  • High-entropy nanozymes offer a promising strategy to enhance nanozyme catalysis.
  • Tunable electronic structures and synergistic effects in HEAs are key to improved catalytic performance.
  • HEzymes show significant potential for advanced nano-bio analysis and digital biosensing.