Related Experiment Video
Updated: Jun 17, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
Translating Anti-Inflammatory Strategies for Atherosclerosis: Deep Phenotyping, Next-Generation Drug Targets, and
Yaw Asare1, Marios K Georgakis1,2
1Institute for Stroke and Dementia Research, Ludwig-Maximilians-University (LMU) Hospital, LMU Munich, 81377 Munich, Germany.
Insights
Atherosclerosis, a key factor in cardiovascular disease (CVD), drives conditions like heart attack and stroke. Understanding its mechanisms is crucial for preventing these life-threatening events.
Area of Science:
- Cardiovascular Science
- Pathology
- Medical Research
Background:
- Atherosclerosis is the primary cause of cardiovascular disease (CVD).
- CVD encompasses serious conditions such as myocardial infarction and ischemic stroke.
- Identifying the core pathology of atherosclerosis is vital for disease management.
Abstract:
Atherosclerosis is the main pathology underlying cardiovascular disease (CVD), including myocardial infarction and ischemic stroke [...].
Related Concept Videos
Inflammation
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Targets for Drug Action: Overview
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...

