Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Plant-based diet, metabolic signature, genetic susceptibility, and risk of musculoskeletal disorders: a large-scale population-based prospective cohort study.

Frontiers in public health·2026

Same author

Nanomotors with Dual Targeting and Self-Feedback Degradation Performance for the Treatment of Sepsis.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Electronic structure modulation of Ni-decorated Cu nanowire electrode for efficient nitrate-to-ammonia conversion in neutral media.

Journal of colloid and interface science·2026

Same author

A multi-trait polygenic risk score enhances osteoporosis risk prediction in East Asian population.

Journal of advanced research·2026

Same author

Distinct Mediating Roles of Hypertension in Arterial Stiffness Mechanisms Associated with Cardiovascular Disease Risk: A Community-Based Cohort Study.

American journal of hypertension·2026

Same author

Development and temporal validation of an interpretable prediction model for delayed diagnosis of benign paroxysmal positional vertigo: a retrospective study from Beijing, China.

Preventive medicine reports·2026

Search research articles

Related Experiment Video

Updated: Jun 17, 2025

Mouse Round Spermatid Injection

Mouse Round Spermatid Injection

Published on: January 26, 2024

Engineered nanoparticles potentials in male reproduction.

Feifei Zhao¹, Mengyu Fan², Zhiyang Jing²

¹Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

|August 9, 2024

Summary

Nanocarriers offer a promising solution for treating testicular disorders, a growing cause of male infertility. These advanced delivery systems overcome the blood-testis barrier to improve drug efficacy and reduce side effects.

Keywords:

blood–testis barrier drug delivery infertility diseases nanoparticles testicular diseases

More Related Videos

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Published on: March 21, 2021

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering

Published on: September 16, 2016

Related Experiment Videos

Last Updated: Jun 17, 2025

Mouse Round Spermatid Injection

Mouse Round Spermatid Injection

Published on: January 26, 2024

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Published on: March 21, 2021

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering

Published on: September 16, 2016

Area of Science:

Reproductive Medicine
Nanotechnology
Drug Delivery Systems

Background:

Aging population faces increasing fertility issues.
Testicular disorders are a key factor in male infertility.
Current treatments have limitations like side effects and tissue damage.

Purpose of the Study:

To review the potential of nanocarriers for treating testicular diseases.
To highlight nanocarriers as a novel therapeutic approach.

Main Methods:

Focus on nanocarrier properties: biocompatibility, membrane penetration.
Discuss surface ligand modification for targeting the blood-testis barrier.
Review applications of nanocarriers in delivering therapeutic agents to testicular tissue.

Main Results:

Nanocarriers can overcome the blood-testis barrier.
They enhance drug bioavailability and therapeutic efficacy.
Potential to mitigate side effects of conventional treatments.

Conclusions:

Nanocarriers are crucial for effective therapeutic agent delivery to testicular tissue.
They represent a significant advancement in treating testicular diseases.