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Published on: February 26, 2013
Impact of initial high sensitivity C-reactive protein on outcomes in nonvalvular atrial fibrillation: an
Akash Batta1, Juniali Hatwal2, Prashant Panda3
1Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana, 141001, India.
Insights
Initial high-sensitivity C-reactive protein (hs-CRP) levels predict major adverse cardiac or cerebrovascular events (MACCE) in nonvalvular atrial fibrillation (AF) patients. Elevated hs-CRP identifies individuals at higher risk for these adverse outcomes.
Area of Science:
- Cardiology
- Biomarkers
- Clinical Medicine
Background:
- Nonvalvular atrial fibrillation (AF) is a significant risk factor for cardiovascular and cerebrovascular events.
- Early identification of high-risk AF patients is crucial for timely intervention and improved outcomes.
- High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation with potential prognostic value.
Purpose of the Study:
- To evaluate the clinical impact of baseline hs-CRP levels on the occurrence of major adverse cardiac or cerebrovascular events (MACCE) in treatment-naive nonvalvular AF patients.
- To determine if hs-CRP is an independent predictor of MACCE in this patient cohort.
- To assess the utility of hs-CRP for early risk stratification in nonvalvular AF.
Main Methods:
- Prospective, observational, single-center study design.
- Inclusion of recently diagnosed, treatment-naive nonvalvular AF patients.
- Measurement of baseline hs-CRP levels and 24-month follow-up for MACCE.
Main Results:
- A total of 126 patients were enrolled, with a mean age of 66.2 years.
- The composite MACCE outcome occurred in 17.7% of patients at 24 months.
- Regression analysis identified raised initial hs-CRP as an independent predictor of MACCE (OR: 1.569, 95% CI: 1.289-1.912, p < 0.001).
Conclusions:
- Elevated baseline hs-CRP is an independent predictor of MACCE in nonvalvular AF patients over 24 months.
- hs-CRP can aid in the early identification of nonvalvular AF patients at higher risk for adverse events.
- Integrating hs-CRP measurement into routine clinical practice may enhance risk stratification and management strategies for AF.
Abstract:
Aim: The index study aimed to investigate the clinical impact of initial high-sensitivity C-reactive protein (hs-CRP) on outcomes in nonvalvular atrial fibrillation (AF). Methods: Single-center, prospective, observational study recruiting all recently diagnosed treatment-naive AF patients. Hs-CRP was measured at baseline and patients were followed for 24 months. Results: A total of 126 patients with a mean age of 66.2 (±12.0) years were enrolled. The composite outcome of major adverse cardiac or cerebrovascular events (MACCE) occurred in 19 (17.7%) at 24 months. Raised initial hs-CRP emerged as an independent predictor of MACCE on regression analysis (OR: 1.569, 95% CI: 1.289-1.912; p < 0.001). Conclusion: Raised hs-CRP was an independent predictor of MACCE at 24 months. It allows for early identification of high-risk patients.
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