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Report From the Second Global Scientific Conference on Clinical Trial Design and Outcome Measures for

Silvia Cerolini1, Jean Bennett2, Bart P Leroy3

  • 1Eyes on the Future, London, UK.

Translational Vision Science & Technology
|August 9, 2024
PubMed
Abstract

Translational Relevance:

A multi-stakeholder, patient centric approach will be critical to the design of future successful clinical trials with outcome measures relevant to the RDH12-IRD population.

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

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