Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

2.3K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.3K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

2.5K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.5K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing mechanobiology from single molecules to complex cellular systems.

Nature nanotechnology·2026
Same author

Event-based spatiotemporal networks for modelling emergent phenomena in complex systems.

Nature communications·2026
Same author

Injury-induced electrochemical coupling triggers organ growth.

Science advances·2026
Same author

Regulation of epithelial tissue homeostasis by active transepithelial transport.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Patterned invagination prevents mechanical instability during gastrulation.

Nature·2025
Same author

Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

Erratum for the Research Article "Assessing the health risks of rice cadmium content standards in China" by H. Chu <i>et al</i>.

Science advances·2026
Same journal

Erratum for the Research Article "Developmental regulation of Erk signaling by mitotic kinases" by F. Chen <i>et al</i>.

Science advances·2026
Same journal

Magnetically levitated metasurface enabling tangible and bidirectional human-machine interaction.

Science advances·2026
Same journal

A general photoinduced manganese-catalyzed platform for the sequential difunctionalization of [1.1.1]propellane.

Science advances·2026
Same journal

Turning sound and force into light with AlN:Mn<sup>2+</sup> mechanoluminescence.

Science advances·2026
Same journal

Extreme dominance of Earth-origin heavy ions in the intense ring current near the Earth during the May 2024 super geomagnetic storm.

Science advances·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2025

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

9.3K

Active shape programming drives Drosophila wing disc eversion.

Jana F Fuhrmann1,2, Abhijeet Krishna1,2,3, Joris Paijmans4

  • 1Max-Planck Institute for Molecular Cell Biology and Genetics, MPI-CBG, Pfotenhauerstrasse 108, 01307 Dresden, Germany.

Science Advances
|August 9, 2024
PubMed
Summary
This summary is machine-generated.

Scientists discovered how 3D tissue shapes form during development, using a "shape programming" mechanism in fruit fly (Drosophila) wing discs. Active cell rearrangements drive this process, offering insights for both developmental biology and material science.

More Related Videos

Long-Term Live Imaging of Drosophila Pupal Leg Development After Puparium Removal
05:20

Long-Term Live Imaging of Drosophila Pupal Leg Development After Puparium Removal

Published on: January 17, 2025

587
Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster
10:10

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Published on: September 20, 2014

26.7K

Related Experiment Videos

Last Updated: Jun 17, 2025

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

9.3K
Long-Term Live Imaging of Drosophila Pupal Leg Development After Puparium Removal
05:20

Long-Term Live Imaging of Drosophila Pupal Leg Development After Puparium Removal

Published on: January 17, 2025

587
Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster
10:10

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Published on: September 20, 2014

26.7K

Area of Science:

  • Developmental biology
  • Biophysics
  • Materials science

Background:

  • Understanding 3D tissue shape formation during animal development is a key biological question.
  • Epithelial tissues undergo complex shape changes, but the underlying mechanisms are not fully understood.

Purpose of the Study:

  • To investigate the mechanism of 3D epithelial shape change during animal development.
  • To explore the analogy between biological tissue morphogenesis and engineered "shape programmable" materials.

Main Methods:

  • Studied the eversion of the Drosophila wing disc pouch, transforming from a dome to a curved fold.
  • Quantified 3D tissue shape changes and mapped cellular behaviors using cellular topology.
  • Employed a physical model inspired by shape programming principles.

Main Results:

  • Active, in-plane cellular rearrangements were identified as the primary driver of pouch eversion.
  • Disruption of cell rearrangements via MyoVI knockdown impaired morphogenesis, validating the findings.
  • Demonstrated that epithelial shape change can be explained by principles analogous to "shape programming" in materials.

Conclusions:

  • "Shape programming" through active cellular events is a viable mechanism for animal tissue morphogenesis.
  • The study provides a novel link between developmental biology and the design of programmable materials.
  • Natural patterns in tissue development may offer design strategies for advanced materials.