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Updated: Jun 17, 2025
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Hyalinizing clear cell carcinoma in the nasopharynx: A case report and literature review
Yu-Wei Chang1, Hsing-Mei Wu1,2
1Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan.
Rationale:
Hyalinizing clear cell carcinoma (HCCC) arising from a minor salivary gland is a rare malignant neoplasm. Most HCCC has been reported in the palate and tongue base, and only rarely in the nasopharynx. Here, we report a rare case of nasopharyngeal HCCC.
Patient Concerns:
A 44-year-old male who complained of otorrhea and aural fullness for 5 years was found to have a nasopharyngeal mass.
Diagnoses:
HCCC by fluorescence in situ hybridization analysis.
Interventions:
Surgical resection plus concurrent chemotherapy and radiation therapy were administered.
Outcomes:
The patient recovered well with symptoms improved at postoperative follow-up.
Lessons:
HCCC should be included in the differential diagnosis of nasopharyngeal mass. Overall, the prognosis of HCCC is positive after tumor resection and adequate management.
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