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Updated: Jun 17, 2025

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
Refractory Status Epilepticus in a Patient With Aducanumab-Induced Amyloid-Related Imaging Abnormalities
Joel Neves Briard1, Antoine Duquette1, Romain Cayrol1
1From the Department of Medicine (J.N.B.), Neuroscience (A.D., S.L.-R.), and Pathology and Cellular Biology (R.C.), Université de Montréal, Canada.
A patient receiving aducanumab for Alzheimer disease developed fatal super-refractory status epilepticus due to severe amyloid-related imaging abnormalities (ARIA). Vigilance in interpreting surveillance imaging is crucial for anti-amyloid therapies.
Area of Science:
- Neurology
- Neuroscience
- Pharmacology
Background:
- Amyloid-related imaging abnormalities (ARIA) are a known risk associated with anti-amyloid therapies.
- Super-refractory status epilepticus (SRSE) is a rare but severe neurological emergency.
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