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Felodipine in hypertension
European Journal of Clinical Pharmacology
|January 1, 1985
Summary
Felodipine effectively lowered blood pressure in hypertensive patients. A daily dose of 15 mg demonstrated hypotensive effects with manageable side effects, indicating its potential as a treatment.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
Background:
- Hypertension remains a significant global health concern.
- Selective arteriolar dilators are crucial in managing blood pressure.
Purpose of the Study:
- To evaluate the hypotensive effects and duration of action of felodipine.
- To assess the safety and tolerability of different felodipine dosages.
Main Methods:
- A study involving 13 hypertensive patients.
- Two treatment regimens were used: 5 mg and 10 mg of felodipine, administered three times daily.
- Blood pressure, heart rate, and plasma noradrenaline levels were monitored.
Main Results:
- Both 5 mg and 10 mg regimens significantly reduced mean blood pressure.
- Heart rate increased as blood pressure decreased, with a less pronounced effect at lower doses.
- Increased plasma noradrenaline levels correlated negatively with blood pressure reduction, suggesting baroreceptor reflex involvement.
- The 10 mg regimen led to severe headaches in most patients, halting recruitment.
Conclusions:
- Felodipine, particularly at a divided daily dose of 15 mg, effectively lowers blood pressure in hypertensive patients.
- Lower doses (5 mg TID) showed a better side effect profile compared to higher doses (10 mg TID).
- Baroreceptor reflex sensitivity influences the hypotensive response to felodipine.