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Updated: Jun 17, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.0K

New promises and challenges in the treatment of advanced non-small-cell lung cancer

May-Lucie Meyer1, Bailey G Fitzgerald2, Luis Paz-Ares3

  • 1Center for Thoracic Oncology, Tisch Cancer Institute, Mount Sinai Health System, New York City, NY, USA.

Lancet (London, England)
|August 9, 2024
PubMed

Insights

Advanced non-small-cell lung cancer (NSCLC) treatments have improved with targeted therapies and immunotherapies. Challenges persist in personalized treatment selection, resistance, cost, and accessibility for optimal patient outcomes.

Area of Science:

  • Oncology
  • Pharmacology
  • Immunology

Background:

  • Advanced non-small-cell lung cancer (NSCLC) treatment has seen significant progress.
  • Targeted therapies and immunotherapies are key advancements.

Purpose of the Study:

  • To review current and emerging treatments for advanced NSCLC.
  • To highlight challenges in optimizing NSCLC therapy.

Main Methods:

  • Literature review of targeted therapies, immunotherapies, and novel treatment modalities.
  • Analysis of current treatment guidelines and future therapeutic directions.

Main Results:

  • Tyrosine kinase inhibitors (TKIs) evolve through generations to overcome resistance.
  • Immune checkpoint inhibitors (ICIs) are crucial for NSCLC without actionable mutations.
  • New agents like antibody-drug conjugates (ADCs), bispecific antibodies, T-cell engagers, cellular therapies, cancer vaccines, and external devices are emerging.

Conclusions:

  • Despite progress, challenges in predictive biomarker identification hinder personalized treatment.
  • Addressing treatment resistance, cost, and accessibility is crucial for improving NSCLC care.

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