Related Experiment Video

Updated: May 5, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.4K

ADVANCE: a biomedical informatics approach to investigate acute kidney injury in infants

Jennifer A Rumpel1, Sofia Perazzo2, Jonathan Bona3

  • 1University of Arkansas for Medical Sciences, Little Rock, AR, USA. JARumpel@uams.edu.

Pediatric Research
|August 9, 2024
PubMed

Insights

A new database, ADVANCE, was created to study acute kidney injury (AKI) in infants in neonatal intensive care units (NICUs). This tool helps analyze AKI

Area of Science:

  • Neonatal research
  • Biomedical informatics
  • Pediatric nephrology

Background:

  • Acute kidney injury (AKI) affects up to 50% of infants in neonatal intensive care units (NICUs).
  • AKI in neonates is linked to increased mortality and prolonged hospital stays.
  • Understanding AKI's impact in Level-IV NICUs is crucial for vulnerable infants.

Purpose of the Study:

  • To develop a comprehensive relational database for studying AKI in infants admitted to Level-IV NICUs.
  • To create a granular dataset for analyzing the effects of AKI on neonates.
  • To establish a research tool for investigating AKI epidemiology in a large cohort.

Main Methods:

  • A biomedical informatics approach was used to build the ADVANCE relational database.
  • Data from the Children's Hospitals Neonatal Database were linked with electronic health records from nine centers.
  • The database integrates AKI-specific data for a detailed analysis of neonatal outcomes.

Main Results:

  • The study cohort includes 24,870 infants with a median gestational age of 37 weeks.
  • The cohort has a male predominance (57%) and diverse maternal ethnicity (9.8% Hispanic).
  • Overall in-hospital mortality was 5.8%.

Conclusions:

  • The ADVANCE relational database is an innovative tool for studying AKI epidemiology in infants.
  • This database facilitates rigorous research on risk factors and outcomes of AKI in a vulnerable population.
  • The methodology highlights the successful integration of multi-center data for neonatal health research.
Abstract

More Related Videos

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.2K
Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

1.5K

Related Concept Videos

Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
1.5K
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.4K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2.3K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
559
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
527
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
788