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From guidelines to radiology practice: navigating the 2023 ASCO guidelines for advanced gastroesophageal cancer and

Charit Tippareddy1,2, Orlando M Martinez3, Andrew R Benza4,3

  • 1Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 1110 Euclid Ave, Cleveland, OH, 44106, USA. Charit.Tippareddy2@uhhospitals.org.

Abdominal Radiology (New York)
|August 9, 2024
PubMed

Insights

The 2023 American Society of Clinical Oncology guidelines for advanced gastroesophageal cancer emphasize precision medicine. This review details imaging assessments, treatment efficacy, and adverse effects for radiologists.

Area of Science:

  • Oncology
  • Radiology
  • Gastroenterology

Background:

  • The American Society of Clinical Oncology (ASCO) released updated guidelines in 2023 for advanced gastroesophageal (GE) cancer treatment.
  • These guidelines mark a significant shift towards targeted therapeutics and precision medicine in GE cancer care.

Purpose of the Study:

  • To provide an imaging-based review of recent advancements in GE cancer management.
  • To familiarize radiologists with developing treatment paradigms, imaging assessments, and treatment-related adverse effects.
  • To equip radiologists with knowledge to support oncologists in precision medicine decisions.

Main Methods:

  • Review of current literature and guidelines on advanced GE cancer treatment.
  • Imaging-based analysis of treatment efficacy and adverse effects.
  • Case-based examples illustrating chemotherapy, radiation, and surgical complications.

Main Results:

  • Modern treatments for GE cancer are increasingly personalized, utilizing targeted therapies.
  • Radiologists must be aware of specific adverse effects, including chemotherapy-associated pneumonitis, radiation esophagitis, and anastomotic failure.
  • Imaging plays a crucial role in assessing treatment response and managing complications.

Conclusions:

  • Radiologists are essential members of the multidisciplinary team managing GE cancer.
  • Understanding the imaging manifestations of novel therapies and their toxicities is critical.
  • This review provides a framework for radiologists to contribute effectively to precision medicine in GE oncology.
Keywords:
Gastroesophageal junctionImmunotherapyMedical oncologyPrecision medicineRadiotherapyReview

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