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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Published on: January 22, 2018

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Emerging Therapeutic Targets and Future Directions in Advanced Gastric Cancer: A Comprehensive Review

Margherita Ratti1, Elena Orlandi1, Ilaria Toscani1

  • 1Oncology and Hematology Department, Piacenza General Hospital, Via Taverna 49, 29121 Piacenza, Italy.

Cancers
|August 10, 2024
PubMed

Insights

Advanced gastric cancer (GC) treatment is improving with new molecular and immunologic targets. Personalized therapies, including immunotherapy and targeted agents, offer better outcomes for patients with metastatic disease.

Area of Science:

  • Oncology
  • Gastroenterology
  • Immunology

Background:

  • Metastatic gastric cancer (GC) presents a significant clinical challenge with limited therapeutic options and poor prognosis.
  • Late-stage diagnosis often precludes curative surgical intervention.
  • Recent advances in understanding molecular and immunological criteria are reshaping treatment strategies.

Purpose of the Study:

  • To review current molecular and immunological targets for systemic treatment of metastatic gastric cancer.
  • To highlight recent advancements and future directions in gastric cancer therapy.
  • To provide a comprehensive understanding of therapeutic options for advanced GC.

Main Methods:

  • Review of current clinical practice guidelines and literature.
  • Analysis of immunologic and molecular classifications of gastric cancer.
  • Discussion of established and emerging therapeutic targets and agents.

Main Results:

  • Gastric cancer classification now incorporates programmed cell death 1 (PD-1), microsatellite instability (MSI), and human epidermal growth factor receptor 2 (HER2) status.
  • Immune checkpoint inhibitors combined with chemotherapy have improved outcomes.
  • Personalized treatment strategies based on molecular profiles are becoming standard.

Conclusions:

  • The identification of specific molecular and immunological targets allows for personalized treatment selection in advanced gastric cancer.
  • Future approaches like circulating tumor DNA (ctDNA) monitoring, novel targeted agents (FGFR, MET), CAR-T cells, and cancer vaccines hold promise.
  • A comprehensive understanding of current and future therapeutic strategies is crucial for improving patient outcomes in metastatic GC.
Keywords:
CAR-T cellscancer vaccinesctDNAimmunological targetsmetastatic gastric cancermolecular targets

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