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Related Experiment Video

Updated: Jun 8, 2026

A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

Published on: July 15, 2021

Complete Thoracic Ectopia Cordis in Two Lambs.

Liz de Albuquerque Cerqueira¹, Isabel Luana de Mâcedo¹, Davi Emanuel Ribeiro de Sousa¹

¹Veterinary Pathology Laboratory, College of Agronomy and Veterinary Medicine, Universidade de Brasília, Brasília 70910-900, Distrito Federal, Brazil.

Animals : an Open Access Journal From MDPI

|August 10, 2024

Summary

This summary is machine-generated.

Ectopia cordis (EC), a rare congenital heart defect, was diagnosed in two newborn lambs. Despite surgical attempts, both lambs experienced fatal outcomes due to the severity of this cardiac anomaly.

Keywords:

cardiac anomaly cleft congenital defect malformation ovine sheep

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Last Updated: Jun 8, 2026

A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

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Published on: July 15, 2021

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Published on: March 17, 2023

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

Published on: December 22, 2023

Area of Science:

Veterinary Pathology
Congenital Abnormalities
Sheep Medicine

Background:

Congenital heart defects are globally reported in animals and humans.
Ectopia cordis (EC) is an extremely rare congenital defect in sheep, involving heart exteriorization through a thoracic cleft.

Observation:

Two cases of complete thoracic ectopia cordis in newborn lambs were presented.
Lambs showed exteriorized hearts without pericardial coverage, within a thoracic cleft.
Histological examination revealed epicardial thickening, edema, hemorrhage, and inflammation in one case.

Findings:

Complete thoracic ectopia cordis in sheep is exceptionally rare.
The condition presented with exteriorized hearts and associated fibrous tissue.
Histopathology indicated significant inflammatory and degenerative changes.

Implications:

Ectopia cordis in lambs has a poor prognosis, often resulting in fatal outcomes.
This report highlights the diagnostic features and challenges in managing EC in sheep.
Further research into the genetic and teratogenic factors of EC in sheep may be warranted.