Multifunctional Biocomposites: Synthesis, Characterization, and Prospects for Regenerative Medicine and Controlled...

Area of Science:

• Biomaterials Science
• Materials Chemistry
• Regenerative Medicine

Background:

• Development of advanced composite biomaterials is crucial for biomedical applications.
• Incorporating antimicrobial agents into biomaterials enhances their therapeutic potential.
• Controlled drug delivery systems are needed for sustained therapeutic effects.

Purpose of the Study:

• To synthesize and characterize novel multifunctional composite biomaterials.
• To evaluate the in situ transformation, antibiotic incorporation, and release kinetics.
• To assess the antibacterial activity and biocompatibility of the developed biomaterials.

Main Methods:

• Preparation of dicalcium phosphate (DCPD) and bioactive silicate glass composites.
• Characterization using X-ray diffraction, FTIR, zeta potential, and UV-Vis spectrophotometry.
• Antibiotic release studies in simulated body fluid (SBF) and in vivo toxicity tests in mice.

Main Results:

• Successful in situ transformation of DCPD into an apatitic phase within the silicate matrix.
• Demonstrated controlled and prolonged release of streptomycin sulfate for up to 37 days (755 ppm).
• Exhibited potent broad-spectrum antibacterial activity and good biocompatibility in mice.

Conclusions:

• The developed composite biomaterials show significant promise for tissue engineering, drug delivery, and implant applications.
• The integration of antibiotics ensures prolonged antibacterial efficacy, addressing infection risks.
• This research offers innovative synthetic strategies for advanced biomaterials in regenerative medicine.