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Unraveling the Interaction between Inflammation and the Cardiometabolic Index in Older Men: A Pilot Study

Rafael L Carvalho1, Tábatta R P Brito2, Jônatas B Amaral3

  • 1Postgraduate Program in Biomedical Engineering, Anhembi Morumbi University, Technological Innovation Park, São José dos Campos 12247-016, SP, Brazil.

Nutrients
|August 10, 2024
PubMed

Insights

Obesity exacerbates inflammation in older men. In normal-weight older men, cytokines like IL-6 and IL-10 influence cardiometabolic index (CMI), an effect blunted by obesity.

Area of Science:

  • Gerontology
  • Cardiology
  • Immunology

Background:

  • Cardiometabolic diseases and chronic inflammation are major public health concerns, especially in aging populations.
  • Obesity is a significant risk factor for both cardiometabolic and inflammatory conditions.
  • Inflammaging, the chronic inflammatory state associated with aging, is exacerbated by obesity.

Purpose of the Study:

  • To investigate the relationship between systemic inflammatory status and cardiometabolic index (CMI) in older men.
  • To compare inflammatory markers and CMI between older men with normal weight and those with obesity.
  • To determine the influence of specific cytokines on CMI in different weight groups.

Main Methods:

  • Observational cross-sectional study involving older men aged 71.79 ± 7.35 years.
  • Participants categorized into normal weight (NW, n = 34) and obesity (O, n = 32) groups.
  • Assessment of circulating pro- and anti-inflammatory cytokines and cardiometabolic index (CMI).
  • Multivariate regression analysis to identify factors influencing CMI.

Main Results:

  • The obesity group exhibited significantly higher inflammatory status and CMI compared to the normal weight group (p < 0.0001).
  • Positive correlations were observed between pro- and anti-inflammatory cytokines in both groups.
  • In the normal weight group, IL-6 and IL-10 significantly influenced CMI (p = 0.0003 and p = 0.0030, respectively).
  • No significant influence of these cytokines on CMI was found in the obesity group.

Conclusions:

  • Obesity significantly contributes to inflammaging in older men.
  • Cytokine influence on CMI is evident in older men with normal weight.
  • The heightened pro-inflammatory state in obese older men may interfere with the cytokine-CMI relationship.

Keywords:
IL-10agingcardiometabolic indexinflammaginginflammationinflammatory cytokinemetaflammationobesity

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