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Published on: February 27, 2014
Oat Beta-Glucan Dietary Intervention on Antioxidant Defense Parameters, Inflammatory Response and Angiotensin
Michał Oczkowski1, Katarzyna Dziendzikowska1, Anna Pasternak-Winiarska1
1Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW), Nowoursynowska 166, 02-787 Warsaw, Poland.
Abstract:
Male infertility represents a significant public health concern. There is a negative impact of inflammatory bowel diseases (IBDs) on the male reproductive system. The aim of this study was to investigate whether oat beta-glucan (OBG) with different molar mass can modulate parameters of antioxidant defense and inflammatory response in the testes of adult Sprague-Dawley rats with TNBS-induced colitis and whether the OBG intervention can modulate the inflammatory response in association with the RAS system. Results: higher testicular superoxide dismutase (SOD), glutathione reductase (GR) activities and glutathione (GSH) concentration, and lower testosterone (T) level and glutathione peroxidase (GPx) activity, were observed in rats with colitis than in healthy control ones. TNBS-induced colitis resulted in decreased the angiotensin 1-7 (ANG 1-7) level in the testes of rats fed with low-molar mass OBG compared to control animals. Conclusions: although colitis induced moderate pro-oxidant changes in the gonads, it seems plausible that dietary intervention with different fractions of oat beta-glucans mass may support the maintenance of reproductive homeostasis via the stimulation of the local antioxidant defense system.
Insights
Dietary oat beta-glucan (OBG) may support male reproductive health during inflammatory bowel disease (IBD). OBG intervention helped maintain antioxidant defense in rat testes, potentially aiding reproductive homeostasis.
Area of Science:
- Reproductive biology
- Gastroenterology
- Nutritional science
Background:
- Inflammatory bowel diseases (IBDs) negatively impact male reproductive function.
- Male infertility is a significant public health issue.
- Oxidative stress and inflammation are implicated in IBD-associated male infertility.
Purpose of the Study:
- To investigate the effect of oat beta-glucan (OBG) with varying molar masses on testicular antioxidant defense and inflammation in rats with TNBS-induced colitis.
- To determine if OBG modulates the inflammatory response in conjunction with the renin-angiotensin system (RAS).
Main Methods:
- Induction of colitis in Sprague-Dawley rats using TNBS.
- Administration of OBG with different molar masses.
- Assessment of testicular antioxidant parameters (superoxide dismutase, glutathione reductase, glutathione peroxidase, glutathione).
- Measurement of testosterone levels and angiotensin 1-7 (ANG 1-7).
Main Results:
- Colitis led to increased testicular superoxide dismutase, glutathione reductase, and glutathione concentrations.
- Colitis also resulted in decreased testosterone levels and glutathione peroxidase activity.
- Low-molar mass OBG intervention decreased testicular angiotensin 1-7 levels compared to controls.
Conclusions:
- Colitis induces moderate pro-oxidant changes in the testes.
- Dietary intervention with oat beta-glucans may support reproductive homeostasis.
- OBG may exert its beneficial effects by stimulating the local antioxidant defense system.
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