The Gender Gap in the Relationship between Metabolic Syndrome and Restrictive Ventilatory Defects
Ya-Chun Chu1,2, Chi-Chiang Yang2,3, Shaw-Ji Chen2,4,5
1Department of Respiratory Therapy Center, Taitung MacKay Memorial Hospital, No. 1, Lane 303, Changsha Street, Taitung City 95054, Taiwan.
Nutrients
|August 10, 2024
Summary
Metabolic syndrome significantly increases the risk of restrictive ventilatory defects, particularly in men with abdominal obesity and women with dysglycemia. This highlights the importance of managing metabolic health for lung function.
Area of Science:
- Pulmonary Medicine
- Metabolic Health
- Sex-Based Physiology
Background:
- Physiological differences between sexes necessitate sex-stratified research.
- Metabolic syndrome is a growing public health concern.
- Ventilatory defects can significantly impair quality of life.
Purpose of the Study:
- To investigate the effect of metabolic syndrome on ventilatory defects.
- To stratify these effects by sex.
- To identify specific metabolic abnormalities associated with pulmonary function decline.
Main Methods:
- Nationwide, pooled, cross-sectional study utilizing Taiwan Biobank data.
- Analysis of 45,788 participants (aged ≥30 years).
- Logistic regression models to assess the risk of restrictive and obstructive ventilatory defects in individuals with and without metabolic syndrome, with sex-stratification.
Main Results:
- Metabolic syndrome prevalence was 15.9% (higher in men).
- Metabolic syndrome increased the risk of restrictive ventilatory defects by 35% (OR, 1.35).
- Elevated blood pressure, triglyceride abnormalities, abdominal obesity (men), and dysglycemia (women) were key predictors.
Conclusions:
- Metabolic syndrome is a significant predictor of impaired pulmonary function and restrictive ventilatory defects.
- The risk of ventilatory defects escalates with the number of metabolic abnormalities.
- Sex-specific metabolic factors contribute to restrictive ventilatory defects, emphasizing tailored management strategies.
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