Bone Marrow Disseminated Tumor Cell Detection Is Beneficial for the Early Finding of Bone Metastasis and Prognosis
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View abstract on PubMed
Summary
This summary is machine-generated.Sensitive SE-iFISH detects disseminated tumor cells (DTCs) in bone marrow, aiding early metastasis detection. High CK18+ DTC counts in breast cancer patients indicate a poor prognosis.
Area Of Science
- Oncology
- Molecular Biology
- Medical Imaging
Background
- Disseminated tumor cells (DTCs) are implicated in tumor recurrence and metastasis.
- Current imaging methods struggle with early DTC detection due to low numbers and dormancy.
Purpose Of The Study
- To evaluate the SE-iFISH method for detecting bone marrow DTCs (mDTCs) in breast and prostate cancer patients.
- To compare SE-iFISH with imaging for predicting metastasis and patient prognosis.
Main Methods
- Utilized SE-iFISH (sensitive enumeration of interphase fluorescent in situ hybridization) to detect mDTCs.
- Compared SE-iFISH findings with conventional imaging results in 15 cancer patients.
Main Results
- SE-iFISH detected mDTCs in patients with and without imaging-confirmed bone metastases.
- CK18 expression was high in mDTCs and low in peripheral circulating tumor cells (pCTCs).
- ≥5 CK18+ mDTCs correlated with significantly poorer overall survival in breast cancer patients (median OS: 22.1 vs. 46.9 months).
Conclusions
- SE-iFISH offers superior sensitivity for mDTC detection compared to conventional methods.
- mDTC detection via SE-iFISH enables earlier identification of tumor cells in bone marrow.
- ≥5 CK18+ mDTCs is a significant prognostic marker for poor outcomes in breast cancer.
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