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Moderate Aerobic Exercise Induces Homeostatic IgA Generation in Senile Mice
Angel J Hernández-Urbán1, Maria-Elisa Drago-Serrano2, Aldo A Reséndiz-Albor3
1Laboratorio de Citometría de Flujo, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
International Journal of Molecular Sciences
|August 10, 2024
Summary
Moderate aerobic exercise (MAE) enhances T-cell-independent IgA production in aging mice, improving intestinal homeostasis by promoting B cells and reducing inflammation. This suggests MAE benefits aging gut immunity.
Area of Science:
- Immunology
- Gastroenterology
- Aging Research
Background:
- T-cell-independent (TI) pathways generate homeostatic IgA crucial for intestinal homeostasis.
- Moderate aerobic exercise (MAE) positively impacts intestinal immunity, but its effect on TI-IgA during aging is unclear.
Purpose of the Study:
- To investigate the long-term effects of MAE on TI-IgA production in young and aging mice.
- To determine how MAE influences B cell populations and molecular factors involved in IgA synthesis and transport in the aging gut.
Main Methods:
- BALB/c mice (young and aging) underwent long-term MAE.
- Lamina propria cells and epithelial cells were analyzed using flow cytometry and RT-qPCR.
- Key molecular factors for class switch recombination, IgA synthesis, and IgA transcytosis were quantified.
Main Results:
- In aging mice, MAE increased B cells, IgA+ B cells, and APRIL levels.
- MAE appeared to downmodulate pro-inflammatory mediators and upregulate polymeric immunoglobulin receptor (pIgR) expression.
- Exercise improved IgA levels and reduced pro-inflammatory cytokine expression in aging mice.
Conclusions:
- Long-term MAE promotes TI-IgA production and ameliorates the inflammatory environment in aging mice.
- MAE supports intestinal homeostasis in senescence by enhancing IgA levels and modulating immune mediators.
- Exercise is a potential strategy to improve gut health during aging.
