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  9. Predictive And Prognostic Markers
  11. Inflammation And Colorectal Cancer: A Meta-analysis Of The Prognostic Significance Of The Systemic Immune-inflammation Index (sii) And The Systemic Inflammation Response Index (siri)

Inflammation and Colorectal Cancer: A Meta-Analysis of the Prognostic Significance of the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI)

Otilia Menyhart1,2, János Tibor Fekete1,2, Balázs Győrffy1,2,3

  • 1Cancer Biomarker Research Group, Institute of Molecular Life Sciences, Hungarian Research Network, 1117 Budapest, Hungary.

International Journal of Molecular Sciences
|August 10, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

High systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) levels indicate worse outcomes for colorectal cancer (CRC) patients. These inflammation markers show promise for predicting CRC prognosis.

Area of Science:

  • Oncology
  • Immunology
  • Biostatistics

Background:

  • Colorectal cancer (CRC) prognosis is variable, even within the same disease stage.
  • Novel systemic inflammation markers, systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), show potential prognostic relevance.

Purpose of the Study:

  • To conduct a comprehensive meta-analysis assessing the prognostic significance of SII and SIRI in colorectal cancer.

Main Methods:

  • Systematic literature search for observational studies on SII and SIRI in CRC.
  • Random effects models used for statistical analysis.
  • Pooled effect sizes reported as hazard ratios (HRs) with 95% confidence intervals (CIs).

Main Results:

  • Meta-analysis of 29 studies (10,091 participants) found high SII associated with worse overall survival (OS) (HR: 1.75) and progression-free/disease-free/recurrence-free survival (PFS/DFS/RFS) (HR: 1.25).
Keywords:
colorectal carcinomamortalityoverall survivalrecurrence-free survival

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  • High SII's association with worse OS was consistent across different treatment strategies, sample sizes, and SII cutoffs.
  • Meta-analysis of 5 studies (2362 participants) revealed high SIRI strongly linked to worse OS (HR: 2.65) and DFS/RFS (HR: 2.04).

    • Conclusions:

    • Both SII and SIRI demonstrate significant promise as prognostic markers for colorectal cancer.
    • Further validation is required to establish their age- and stage-specific utility in clinical practice.
    systematic review