Therapy-Induced Senescence: Novel Approaches for Markers Identification.

Area of Science:

• Oncology
• Cellular Biology
• Immunology

Background:

• Therapy-induced senescence (TIS) is a cellular response to cancer treatments.
• Senescent cells, via their senescence-associated secretory phenotype (SASP), can promote tumor growth and hinder anti-tumor immunity.
• Senescent cancer cells may evade growth arrest, potentially leading to relapse.

Purpose of the Study:

• To review current knowledge on TIS in cancer.
• To identify critical knowledge gaps regarding TIS.
• To discuss advances in discovering TIS biomarkers.

Main Methods:

• Literature review of TIS and senotherapy.
• Analysis of the role of SASP in the tumor microenvironment.
• Exploration of current and novel TIS biomarker discovery approaches.

Main Results:

• TIS can negatively impact cancer therapy outcomes.
• Senotherapy, targeting senescent cells or their SASP, is a promising therapeutic strategy.
• A lack of reliable TIS biomarkers impedes clinical translation of senotherapy.

Conclusions:

• TIS presents a significant challenge in cancer therapy.
• Development of TIS biomarkers is a high priority for clinical senotherapy.
• Further research into TIS biomarkers is essential for improving cancer treatment efficacy.